Reports / Specific Analyses

Dear colleagues,

The 1996-2015 update of the Nationwide Registry for Childhood Hematological Malignancies (NARECHEM-ST, www.narechem.gr) in Greece is available and has been also contributed to the IARC related European Pediatric Cancer Registries (ACCIS, CI5-X CI5plus, EUROCIM και EUROCAR) as well as to interested scientists under certain terms and conditions and following a request addressed to E. Petridou and N. Dessypris.

Reports

  1. Childhood leukemia in Greece (1996-2015): ACUTE LEUKEMIA (ALL & AML)
    · By histological subtype (ALL & AML) , or total
    · Annual crude and age-standardized incidence rates per 1,000,000
    · Age-standardized incidence rates per 1,000,000 by histological subtype (ALL and AML)
    · Age-standardized incidence rates per 1,000,000 by histological subtype (ALL and AML) and gender
    · by age and histological subtype (ALL and AML)

  2. Childhood lymphoma in Greece (1996-2015): LYMPHOMA [HL and NHL]
    · By histological subtype (NHL & HL) , or total
    · Annual crude and age-standardized incidence rates per 1,000,000
    · Age-standardized incidence rates per 1,000,000 by histological subtype (HL - NHL)
    · Age-standardized incidence rates per 1,000,000 of NHL by histological subtype (Burkitt - NHL non-Burkitt)
    · Age-standardized incidence rates per 1,000,000 by histological subtype and gender
    · by age and histological subtype
  3. Childhood central nervous system (CNS) tumors (2010-2015)
    · Number of cases per year
    · Number of cases per histological subtype (N=293)
    · Number of cases per behaviour
    · Annual Crude and Age-Standardised Incidence Rates per 1,000,000
    · Incidence Rates per 1,000,000 by age group and gender
    · Age-Standardised Rates (AIR) per 1,000,000 by behaviour and gender
    · Age-Standardised Rates (AIR) per 1,000,000 by histological subtype and gender (N=293)
    · Annual Age-Standardised Incidence Rates (AIR) per 1,000,000 by behaviour
  4. Childhood Neuroblastomas in Greece (2009-2015): report under construction
  5. Childhood Wilm’s Tumors (Nephroblastomas) in Greece (2009-2015): report under construction


NARECHEM-ST descriptives at a glance:

  • Time trends of childhood leukemias confirm the statistically significant increase observed in Greece during the latest time period with a crude annual increase of 1.5% and an age adjusted annual change of +1% (95%CI:0.0%-2.0%; figures derived from the Poisson regression
  • ALL and AML leukemia subtypes both contribute to the annual incidence increase, though the trend does not reach statistical significance in either of them, possibly due to small numbers
  • Gender and age patterns are in line with literature, Specifically:
    Boys outnumber girls (male/female incidence rate ratio: 1.20) on account mainly of ALL preponderance (male/female incidence rate ratio: 1.27), whereas the gender ratio for AML is 0.80
  • The peak age distribution for ALL is 1-4 years, whereas AML is more prevalent among less than two years infants and adolescents
  • Childhood lymphomas show no increasing trends, but rather fluctuations expected during the study period
  • Non Hodgkin outnumber Hodgkin lymphomas (1.44)
  • Overall, boys outnumber girls by a factor of 2; the gender ratio is 3:1 for Non Hodgkin and 3:2 for Hodgkin lymphoma
  • Lymphomas are rare in early childhood (0-4 years:16.1%) their proportion increases to 34% among children 5-9 years and peak among those 10-14 year of age (50%)


    • The NARECHEM-ST:
      Head: E. Petridou, Prof. of Preventive Medicine and Epidemiology
      Data manager and analyst: N. Dessypris
      Field coordinator and interviewers: E. Bouka, P. Bouka
      Administrator: A. Alexopoulos